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Sage Therapeutics
Sage Therapeutics
(SAGE)
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Clinical Trials
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Revenue by Drug
Marketed Drugs
Therapeutic Areas:
All
Classification:
All
Include Generics:
Trade Name
Drug Name
Approved
Patent Expires
Indication
Apomorphine
Apomorphine
2022-02-23
2023-2036
Parkinson disease
,
Erectile dysfunction
Chlorhexidine
Chlorhexidine
2005-04-25
2024-2027
Periodontal diseases
,
Infectious skin diseases
,
Gram-negative bacterial infections
,
Oral candidiasis
,
Gram-positive bacterial infections
,
Hypercholesterolemia
,
Coronary artery disease
,
Hypertriglyceridemia
,
Hyperlipoproteinemias
Zulresso
Brexanolone
2019-06-17
2029-2037
Postpartum depression
Clinical Trials
Therapeutic Areas:
All
Classification:
All
Approval:
All
Status:
All
Phases:
All
Drug Name
Phase 1
Phase 2
Phase 3
Phase 4
Indication
Brexanolone
psychotic disorders
,
mental disorders
,
alcoholism
,
essential tremor
,
tremor
,
alcohol drinking
,
traumatic stress disorders
,
covid-19
,
respiratory distress syndrome
,
acute lung injury
,
newborn respiratory distress syndrome
,
syndrome
,
post-traumatic stress disorders
,
postpartum depression
,
depression
,
depressive disorder
,
wounds and injuries
,
attention deficit disorder with hyperactivity
Chlorhexidine gluconate
nerve block
,
stomatognathic diseases
,
hypertension
,
prostatic neoplasms
,
heart diseases
,
atrophy
,
disease
,
salivation
,
neoplasm metastasis
,
sars-cov-2
,
pulmonary hypertension
,
pulmonary heart disease
,
diabetic angiopathies
,
retinal vein occlusion
,
macular degeneration
,
diabetic retinopathy
,
gram-positive bacterial infections
,
dentist-patient relations
,
exanthema
,
dental scaling
,
spinal cord injuries
,
quadriplegia
,
myelodysplastic syndromes
,
ovarian neoplasms
,
bone regeneration
,
triple negative breast neoplasms
,
invasive hydatidiform mole
,
premature birth
,
mouth neoplasms
,
cesarean section
,
drug-related side effects and adverse reactions
,
coronavirus infections
,
endometritis
,
colonic neoplasms
,
neuralgia
,
cystic fibrosis
,
nonvital tooth
,
hematologic diseases
,
hiv infections
,
skin ulcer
,
necrosis
,
candidiasis
,
toxemia
,
chronic obstructive pulmonary disease
,
bacterial vaginosis
,
pancreatic neoplasms
,
intractable pain
,
fibrosis
,
metabolic bone diseases
,
preoperative care
,
oropharyngeal neoplasms
,
clostridium infections
,
hyperplasia
,
urinary bladder neoplasms
,
colorectal neoplasms
,
multiple myeloma
,
glioblastoma
,
rectal neoplasms
,
gallbladder neoplasms
,
gastrointestinal neoplasms
,
migraine disorders
,
lysosomal storage diseases
,
gangliosidoses
,
yaws
,
penile prosthesis
,
long term adverse effects
,
drug therapy
,
thrombocytopenia
,
calculi
,
hemorrhoids
,
dengue
,
vulvovaginal candidiasis
,
non-small-cell lung carcinoma
,
squamous cell carcinoma of head and neck
,
sarcoma
,
burkitt lymphoma
,
lymphoproliferative disorders
,
neoplasms
,
halitosis
,
surgical wound
,
dental pulp necrosis
,
periapical periodontitis
,
neonatal sepsis
,
head and neck neoplasms
,
infant mortality
,
burns
,
gingival hemorrhage
,
mouth diseases
,
stomach neoplasms
,
tooth loss
,
fever
,
esophageal neoplasms
,
pain management
,
adenocarcinoma
,
amyloid plaque
,
deglutition disorders
,
aphthous stomatitis
,
female genital diseases
,
obstetric labor complications
,
lung neoplasms
,
patient compliance
,
malocclusion
,
pregnancy
,
periodontics
,
leukemia
,
laparotomy
,
radiodermatitis
,
acanthamoeba keratitis
,
immunologic cytotoxicity
,
conization
,
dental calculus
,
anesthesia
,
pathologic processes
,
pelvic organ prolapse
,
dental pulp diseases
,
hallux valgus
,
neutropenia
,
arthritis
,
erectile dysfunction
,
bronchiolitis obliterans syndrome
,
myeloid leukemia acute
,
precursor cell lymphoblastic leukemia-lymphoma
,
eyelid neoplasms
,
neurofibromatosis 1
,
neurofibromatoses
,
neurofibroma
,
periodontal index
,
intraoperative complications
,
neurodevelopmental disorders
,
urinary incontinence
,
pelvic floor disorders
,
taste perception
,
periapical abscess
,
erythema
,
leukocytosis
,
vaginal discharge
,
puerperal infection
,
newborn infant diseases
,
keratitis
,
anodontia
,
peritoneal neoplasms
,
randomized controlled trials as topic
,
infections
,
periodontitis
,
communicable diseases
,
surgical wound infection
,
gingivitis
,
periodontal diseases
,
dental caries
,
dental plaque
,
sepsis
,
ventilator-associated pneumonia
,
pneumonia
,
staphylococcal infections
,
peri-implantitis
,
chronic periodontitis
,
postoperative pain
,
wound infection
,
wounds and injuries
,
catheter-related infections
,
cross infection
,
oral hygiene
,
mucositis
,
bacteremia
,
coronary artery disease
,
breast neoplasms
,
methicillin-resistant staphylococcus aureus
,
staphylococcus aureus
,
bacterial infections
,
covid-19
,
inflammation
,
postoperative complications
,
healthy volunteers/patients
,
stomatitis
,
type 2 diabetes mellitus
,
stroke
,
urinary tract infections
,
periodontal pocket
,
ulcer
,
pain
,
diabetes mellitus
,
gingival recession
,
skin diseases
,
dental implants
,
diabetic foot
,
osteoarthritis
,
impacted tooth
,
hemorrhage
,
respiratory tract infections
,
shoulder pain
,
infectious skin diseases
,
foot ulcer
,
chronic kidney failure
,
abscess
,
soft tissue infections
,
gingival diseases
,
recurrence
,
cardiovascular diseases
,
coronary disease
,
myocardial ischemia
,
microbiota
,
staphylococcal skin infections
,
hand hygiene
,
healthcare-associated pneumonia
,
pulpitis
,
heart failure
,
coronary stenosis
,
replacement arthroplasty knee
,
osteonecrosis
,
knee osteoarthritis
,
bone fractures
,
pharyngitis
,
propionibacterium acnes
,
obesity
,
dry socket
,
biofilms
,
dental implantation
,
tooth discoloration
,
catheterization
,
emergencies
,
headache
,
dermatitis
,
cellulitis
,
acne vulgaris
,
prolapse
,
critical illness
,
replacement arthroplasty hip
,
telangiectasis
,
agnosia
,
leg ulcer
,
myocardial infarction
,
angina pectoris
,
stable angina
,
unstable angina
,
infarction
,
liver neoplasms
,
pancreatitis
,
acute pain
,
ischemia
,
orthopedic procedures
,
lichen planus
,
contraception
,
cerebral hemorrhage
,
asymptomatic infections
,
bacteriuria
,
opioid-related disorders
,
post-dural puncture headache
,
oral ulcer
,
foot dermatoses
,
clostridioides difficile
,
cardiac arrhythmias
,
facial pain
,
epidural analgesia
,
myofascial pain syndromes
,
spondylosis
,
bursitis
,
myocardial stunning
,
st elevation myocardial infarction
,
rib fractures
,
surgical amputation
,
hepatitis b
,
chronic hepatitis b
,
death
,
hypokalemia
,
microbial drug resistance
,
peritoneal dialysis
,
peritonitis
,
intravenous substance abuse
,
oral lichen planus
,
hip fractures
,
open fractures
,
postoperative hemorrhage
,
acute necrotizing pancreatitis
,
pathologic complete response
,
pseudomonas infections
,
pseudomonas aeruginosa
,
dysbiosis
,
postoperative nausea and vomiting
,
home nursing
,
hysterectomy
,
oral surgery
,
hospitalization
,
morbid obesity
,
gynecologic surgical procedures
,
aggressive periodontitis
,
aggression
,
osteitis
,
ingrown nails
,
hepatocellular carcinoma
,
papillomavirus infections
,
human influenza
,
common cold
,
temperature
,
humidity
,
dental pulp capping
,
aspiration pneumonia
,
systemic inflammatory response syndrome
,
tissue adhesions
,
skin irritancy tests
,
local anesthesia
,
atopic dermatitis
,
eczema
,
operative surgical procedures
,
cough
,
thyroid diseases
,
thyroidectomy
,
hoarseness
,
blepharitis
,
wound healing
,
alveolar bone loss
,
syndrome
,
central venous catheters
,
conduction anesthesia
,
vascular diseases
,
catheters
,
congenital abnormalities
,
analgesia
,
xerostomia
,
intratracheal intubation
,
rosacea
,
uterine cervical neoplasms
,
cicatrix
,
thrombosis
,
motor activity
,
bisphosphonate-associated osteonecrosis of the jaw
,
edema
,
cognitive dysfunction
,
low back pain
,
multiple drug resistance
,
respiratory distress syndrome
,
chronic renal insufficiency
,
kidney diseases
,
malnutrition
,
nursing care
,
airway obstruction
,
tooth demineralization
,
rupture
,
peripheral catheterization
,
birth weight
,
respiratory insufficiency
,
tooth diseases
,
atrial fibrillation
,
hydrogen-ion concentration
,
gingival overgrowth
,
skin aging
,
phlebitis
,
neck pain
,
prosthesis-related infections
,
pressure ulcer
,
trismus
,
anxiety disorders
,
acquired immunodeficiency syndrome
,
hiv-2
,
uterine cervical dysplasia
,
blood pressure
,
back pain
,
hip osteoarthritis
,
plantar fasciitis
,
liver diseases
,
inflammatory bowel diseases
,
furunculosis
,
newborn respiratory distress syndrome
,
chronic pain
,
carcinoma in situ
,
male breast neoplasms
,
critical care
,
hepatectomy
,
intubation
,
diabetes complications
,
diabetic neuropathies
,
depressive disorder
,
postpartum hemorrhage
,
actinic keratosis
,
lentigo
,
streptococcus mutans
,
hypertrophy
,
oral candidiasis
,
risk reduction behavior
,
pigmentation disorders
,
spinal anesthesia
,
epidural anesthesia
,
infertility
,
hernia
,
coronary occlusion
,
coronary restenosis
,
reinfection
,
obstructive lung diseases
,
alzheimer disease
,
cardiogenic shock
,
reflex sympathetic dystrophy
,
temporomandibular joint disorders
,
depression
,
hematoma
,
traumatic brain injuries
,
patient satisfaction
,
pilonidal sinus
,
periodontal attachment loss
,
tooth extraction
,
anxiety
,
fissure in ano
,
artificial respiration
,
gastrectomy
,
metabolic syndrome
,
venous insufficiency
,
nervous system neoplasms
,
edentulous jaw partially
,
hyperglycemia
,
photochemotherapy
,
hiv
,
granulomatous mastitis
,
mastitis
,
edentulous jaw
,
acute coronary syndrome
,
arteriosclerosis
,
arterial occlusive diseases
,
patient participation
,
pain perception
,
percutaneous coronary intervention
,
atherosclerosis
,
atrophic vaginitis
,
bundle-branch block
,
benign familial pemphigus
,
brain neoplasms
,
musculoskeletal diseases
,
digestive system diseases
,
pancreatic diseases
,
acute lung injury
,
delirium
,
liver cirrhosis
,
breast carcinoma in situ
,
breast cancer lymphedema
,
lymphedema
,
surgical flaps
,
mammaplasty
,
sacroiliitis
,
metabolome
,
child development
,
health behavior
,
pregnancy rate
,
substance-related disorders
,
hepatitis c
,
hepatitis
,
marijuana abuse
,
marijuana use
,
alcoholism
,
balloon angioplasty coronary
,
major depressive disorder
,
only child
,
coronavirus
,
osteoradionecrosis
,
carcinoma
,
basal cell carcinoma
,
melanoma
,
squamous cell carcinoma
,
hutchinson's melanotic freckle
,
squamous cell neoplasms
,
carcinosarcoma
,
dysplastic nevus syndrome
,
basal cell neoplasms
,
seborrheic keratosis
,
keratosis
,
premature rupture fetal membranes
,
bronchitis
,
segmental mastectomy
,
streptococcus milleri group
,
arthroscopy
,
adiposity
,
breast milk expression
,
feeding behavior
,
body composition
,
growth
,
periapical diseases
,
severe acute respiratory syndrome
,
irritable bowel syndrome
,
dentofacial deformities
,
jaw abnormalities
,
port-wine stain
,
capillary hemangioma
,
conscious sedation
,
regenerative endodontics
,
carpal tunnel syndrome
,
pericoronitis
,
multiple organ failure
,
heart arrest
,
body weight
,
bronchopulmonary dysplasia
,
necrotizing enterocolitis
,
weight gain
,
retinopathy of prematurity
,
enterocolitis
,
carotid stenosis
,
tooth abrasion
,
short bowel syndrome
,
esophageal atresia
,
diaphragmatic hernias congenital
,
calcium metabolism disorders
,
personal satisfaction
,
glaucoma
,
sudden infant death
,
infant death
,
bone resorption
,
skin pigmentation
,
mortality
,
severe acute malnutrition
,
gastroenteritis
,
community-acquired pneumonia
,
dental pins
,
female genital neoplasms
,
spinal injuries
,
hemangioma
,
family relations
,
family conflict
,
heart block
,
hypertrichosis
,
barrett esophagus
,
peptic esophagitis
,
esophagitis
,
ventral hernia
,
replacement arthroplasty
,
hypertrophic cicatrix
,
keloid
,
neointima
,
asphyxia
,
eclampsia
,
asphyxia neonatorum
,
photosensitivity disorders
,
ankle fractures
,
ototoxicity
,
gastroscopy
,
schizophrenia
,
psychotic disorders
,
drug-eluting stents
,
accidental injuries
,
densitometry
,
hereditary congenital and neonatal diseases and abnormalities
,
community-acquired infections
,
fungemia
,
globus sensation
,
perforator flap
,
cardiomyopathies
,
dilated cardiomyopathy
,
acupuncture therapy
,
neuromuscular diseases
,
obesity hypoventilation syndrome
,
hypoventilation
,
polymerase chain reaction
,
enterococcus faecalis
,
type 1 diabetes mellitus
,
hypoglycemia
,
rheumatoid arthritis
,
obstetric delivery
,
ultrasonography
,
muscular atrophy
,
spinal muscular atrophy
,
spinal puncture
,
occlusive dressings
,
probiotics
,
occupational diseases
,
thoracoscopy
,
vaginal diseases
,
funnel chest
,
complex regional pain syndromes
,
portal hypertension
,
focal nodular hyperplasia
,
idiopathic noncirrhotic portal hypertension
,
temporomandibular joint dysfunction syndrome
,
single-tooth dental implants
,
immunohistochemistry
,
forearm injuries
,
autism spectrum disorder
,
vulvovaginitis
,
kidney calculi
,
cigarette smoking
,
blood culture
,
denture stomatitis
,
body image
,
tennis elbow
,
shock
,
brain injuries
,
ischemic stroke
,
hearing loss
,
bilateral hearing loss
,
deafness
,
healthy aging
,
aging
,
urinary retention
,
neurogenic urinary bladder
,
dental enamel hypomineralization
,
occupational stress
,
psychological burnout
,
premenstrual syndrome
,
metabolic diseases
,
dialysis
,
caregiver burden
,
smoking
,
tooth erosion
,
fibromyalgia
,
somatoform disorders
,
vulvar neoplasms
,
condylomata acuminata
,
intestinal diseases
,
hypospadias
,
essential hypertension
,
kangaroo-mother care method
,
replacement arthroplasty shoulder
,
surgical wound dehiscence
,
cardiac surgical procedures
,
patient acceptance of health care
,
athletic injuries
,
venous thrombosis
,
dental occlusion
,
spinal stenosis
,
tendinopathy
,
patella fracture
,
disease progression
,
psychological well-being
,
muscle spasticity
,
nose diseases
,
orthodontics
,
dehydration
,
thirst
,
lipedema
,
central nervous system sensitization
,
insulin resistance
,
intervertebral disc displacement
,
crush injuries
,
laughter therapy
,
vital signs
,
radius fractures
,
wrist fractures
,
laparoscopic cholecystectomy
,
fear
,
cerebral palsy
,
paralysis
,
exercise
,
blood coagulation
,
brain concussion
,
acute kidney injury
,
pulmonary infarction
,
gastrointestinal hemorrhage
,
nutritional support
,
skin transplantation
,
femur head necrosis
,
gingival hyperplasia
,
dentistry
,
glucose metabolism disorders
,
regeneration
,
neuroinflammatory diseases
,
tooth fractures
,
dental anxiety
,
dental care
,
thrombophilia
,
postpartum period
,
subarachnoid hemorrhage
,
anesthesia and analgesia
,
immediate dental implant loading
,
extracorporeal membrane oxygenation
,
urethral stricture
,
tooth ankylosis
,
unerupted tooth
,
removable orthodontic appliances
,
filtration
,
intravenous administration
,
equipment and supplies
,
patient care bundles
,
interdisciplinary communication
,
vascular access devices
,
renal dialysis
,
physical therapy modalities
,
dentures
,
psychological stress
,
vasoconstriction
,
environmental biomarkers
Chlorhexidine
breast neoplasms
,
non-small-cell lung carcinoma
,
periodontitis
,
dental plaque
,
infections
,
communicable diseases
Enoblituzumab
conjunctivitis
,
inclusion conjunctivitis
,
kidney diseases
,
hyperphosphatemia
,
otitis externa
,
otitis
,
mucopolysaccharidosis ii
,
syndrome
Cetylpyridinium chloride
covid-19
,
coronavirus infections
,
amyloid plaque
,
healthy volunteers/patients
,
gingivitis
,
dental plaque
,
type 2 diabetes mellitus
,
periodontal diseases
,
dental caries
Aspartame
substance-related disorders
,
breakthrough pain
,
neoplasms
,
dyspnea
Dimethicone
chronic renal insufficiency
,
colonic neoplasms
,
colonic polyps
RIBAXAMASE
healthy volunteers/patients
,
schizophrenia
Sepranolone
covid-19
,
respiratory distress syndrome
,
acute lung injury
,
newborn respiratory distress syndrome
,
syndrome
Antineoplaston a10
healthy volunteers/patients
,
pharmacokinetics
Histone-arginine methyltransferase carm1
pharmacokinetics
,
chronic obstructive pulmonary disease
,
respiratory aspiration
,
positron-emission tomography
,
anemia
,
alzheimer disease
,
diagnostic imaging
,
medical sociology
,
drug interactions
,
electrocardiography
,
therapeutic equivalency
,
neuroinflammatory diseases
,
pharmacological phenomena
,
dietary fats
,
liver diseases
,
stomach neoplasms
,
hypophosphatemia
,
hematologic neoplasms
,
cystic fibrosis
,
pseudomonas infections
,
biological availability
,
castration-resistant prostatic neoplasms
,
heart failure
,
non-small-cell lung carcinoma
,
breast neoplasms
,
postcoital contraception
,
ovulation inhibition
,
atrial fibrillation
,
lung neoplasms
,
sclerosis
,
parkinson disease
,
small cell lung carcinoma
,
ovarian neoplasms
,
ovarian epithelial carcinoma
,
eczema
,
multiple myeloma
,
plasma cell neoplasms
,
tinnitus
,
leukemia
,
bcr-abl positive chronic myelogenous leukemia
,
myeloid leukemia
,
heart diseases
,
cardiomyopathies
,
libido
,
leiomyoma
,
myofibroma
,
overactive urinary bladder
,
hormonal contraception
,
unplanned pregnancy
,
b-cell lymphoma
,
erythema
,
skin abnormalities
,
myocardial infarction
,
hiv infections
,
acquired immunodeficiency syndrome
,
magnetic resonance angiography
,
tinea pedis
,
left ventricular dysfunction
,
ventricular dysfunction
,
coronary disease
,
myocardial ischemia
,
interstitial lung diseases
,
thyroid neoplasms
,
thyroid diseases
,
pancreatic neoplasms
,
varicose ulcer
,
ulcer
,
leg ulcer
,
dialysis
,
prostatic hyperplasia
,
hyperplasia
,
angina pectoris
,
stable angina
,
ischemic stroke
,
stroke
,
cerebral infarction
,
urologic neoplasms
,
head and neck neoplasms
,
thromboembolism
,
venous thromboembolism
,
pulmonary hypertension
,
hyperphosphatemia
,
chronic renal insufficiency
,
multiple sclerosis
,
non-hodgkin lymphoma
,
lymphoma
,
prostatic neoplasms
,
surgical blood loss
,
venous thrombosis
,
acne vulgaris
,
essential hypertension
,
kidney diseases
,
thrombosis
,
lung diseases
,
hemorrhage
,
endometriosis
,
peripheral vascular diseases
,
postoperative hemorrhage
,
pulmonary embolism
,
cardiovascular diseases
,
hemophilia b
,
spinal cord injuries
,
peripheral arterial disease
,
renal artery obstruction
,
pain
,
bacterial infections
,
low back pain
,
back pain
,
syndrome
,
intraabdominal infections
,
chagas disease
,
chronic progressive multiple sclerosis
,
blood coagulation disorders
,
hormone replacement therapy
,
hyperlipidemias
,
hyperlipoproteinemias
,
choroidal neovascularization
,
myopia
,
degenerative myopia
,
pathologic neovascularization
,
metrorrhagia
,
aspiration pneumonia
,
lung abscess
,
pelvic pain
,
pelvic infection
,
pelvic inflammatory disease
,
dysmenorrhea
,
metabolic bone diseases
,
premenstrual dysphoric disorder
,
diabetic nephropathies
,
proteinuria
,
follicular lymphoma
,
wounds and injuries
,
brain neoplasms
,
cardiovascular abnormalities
,
pathologic constriction
,
onychomycosis
,
vascular diseases
,
memory disorders
,
carotid stenosis
,
pulmonary arterial hypertension
,
burns
,
depression
,
depressive disorder
,
aortic valve stenosis
,
heart valve diseases
,
ventricular outflow obstruction
,
abscess
,
abdominal abscess
,
erectile dysfunction
,
contraception
,
neoplasms
,
hypertension
,
carcinoma
,
hemophilia a
,
healthy volunteers/patients
,
renal cell carcinoma
,
common cold
,
infections
,
atopic dermatitis
,
liver neoplasms
,
pneumonia
,
pharyngitis
,
communicable diseases
,
relapsing-remitting multiple sclerosis
,
hot flashes
,
dermatitis
,
hepatocellular carcinoma
,
urinary tract infections
,
diabetes mellitus
,
coronary artery disease
,
headache
,
type 2 diabetes mellitus
,
colorectal neoplasms
,
menorrhagia
,
postmenopause
,
hypogonadism
,
physiological sexual dysfunction
,
magnetic resonance imaging
,
neoplasm metastasis
,
acute coronary syndrome
,
tension-type headache
,
tonsillitis
,
ischemia
,
peripheral nervous system diseases
,
renal insufficiency
,
chronic bronchitis
,
bronchitis
,
acute disease
,
obesity
,
recurrence
,
respiratory tract infections
,
fever
,
ischemic optic neuropathy
,
optic nerve diseases
,
macular edema
,
edema
,
macular degeneration
,
energy metabolism
,
sinusitis
,
maxillary sinusitis
,
community-acquired pneumonia
,
allergic rhinitis
,
rhinitis
,
allergic rhinitis seasonal
,
medicated intrauterine devices
,
wound healing
,
gene expression
,
cell proliferation
,
constipation
,
fibrosis
,
central nervous system neoplasms
,
photoallergic dermatitis
,
phototoxic dermatitis
,
four-dimensional computed tomography
Surlorian
cognition disorders
,
sleep wake disorders
,
parasomnias
,
disorders of excessive somnolence
,
sleepiness
,
ulcerative colitis
,
colitis
,
ulcer
,
renal cell carcinoma
,
carcinoma
,
pain
,
acute pain
,
hiv infections
,
neoplasm metastasis
,
rheumatoid arthritis
,
chronic renal insufficiency
,
kidney diseases
,
vitamin d deficiency
,
hyperparathyroidism
,
secondary hyperparathyroidism
,
type 1 diabetes mellitus
,
ketosis
,
hypothyroidism
,
healthy volunteers/patients
Corsodyl
catheterization
,
infections
,
communicable diseases
,
hand hygiene
,
skin diseases
,
healthy volunteers/patients
,
ventilator-associated pneumonia
,
wounds and injuries
,
sepsis
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